The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX).
Cyclooxygenase is required to convert arachidonic acid into thromboxanes, prostaglandins, and prostacyclins. The body releases these substances in response to illness and injury.
Naproxen reduces pain, fever, swelling, and inflammation
Therapeutic Indications Of Proxen 250 Mg Tablets
Diseases of joints such as rheumatoid arthritis (including in children), osteoarthritis, ankylosing spondylitis.
Naproxen cannot cure arthritis but is used to give relief of some symptoms such as inflammation, swelling, stiffness, and joint pain
Attacks of gout
Muscle and bone disorders
Painful periods
Method Of Administration Of Proxen 250 Mg Tablets
Take as prescribed
Swallow with or after food
Adults:
Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 500mg-1g a day in two doses at twelve-hour intervals.
Attack of gout: Initially 750mg as a single dose then 250mg every 8 hours until the attack has passed.
Muscle, bone disorders, and painful periods: Initially 500mg as a single dose then 250mg every 6-8 hours as necessary.
Use in children and adolescents Children over 5 years for juvenile rheumatoid arthritis: 10mg per kg of body weight a day
Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
If you take more than you should, talk to a doctor or go to the hospital straight away.
If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
Do not take a double dose (two doses at the same time) to make up for the forgotten dose.
Undesirable Side Effects Of Proxen 250 Mg Tablets
Common side effects:
Headache
Dizziness
Tiredness
Stop taking Naproxen if:
You have indigestion, heartburn, pains in your stomach or other abnormal stomach symptoms, feeling or being sick, diarrhea, worsening of colitis, and Crohn’s disease (you may have an ulcer or inflammation in the stomach or gut)
You pass blood in your feces (stools/motions) or black tarry looking stools (signs of bleeding and perforation of the stomach and intestines)
You vomit any blood or dark particles that look like coffee grounds
You have an allergic reaction: swelling of the face, difficulty breathing
Pregnancy & Breastfeeding Precautions While Taking Proxen 250 Mg Tablets
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Non-Pharmacological Treatments & Advice To Reduce Pain
Massage: A lot of people find relief from gentle massage, and some hospice agencies have volunteers who are trained in massage therapy.
Acupuncture.
Physical therapy
Gel packs.
Warnings & Special Precautions While Taking Proxen 250 Mg Tablets
Talk to your doctor or pharmacist before taking Naproxen tablets if you:
Use other non-steroidal anti-inflammatory medicines (NSAIDs) or any medication which may cause bleeding or ulcers in the stomach
Have a history of gastrointestinal disease e.g. ulcerative colitis, Crohn’s disease
Smoke
Have or have had high blood pressure or any liver, kidney, or heart problems
Have or have had bronchial asthma, other breathing problems, or nasal polyps
Have systemic lupus erythematosus or other connective tissue disorders
Have a blood clotting disorder
You are trying to become pregnant or undergoing investigation of infertility
Tell your doctor if you are taking any of the following medicines:
Aspirin/acetylsalicylic acid to prevent blood clots
Other NSAIDs such as COX-II inhibitors
Medicines that thin the blood or which prevent blood clotting (e.g. heparin or warfarin)
Corticosteroids (e.g. prednisolone), if needed the doctor will reduce the dose of the steroid slowly and monitor for side effects
Diuretics (“water tablets”) (e.g. furosemide)
Medicines to treat high blood pressure (e.g. captopril, ramipril or propranolol, losartan or candesartan)
Cyclosporine or tacrolimus
Mifepristone, do not take NSAIDs 8-12 days after mifepristone
